Inhibition of the recruitment of monocyte-derived macrophages by gene silencing of different receptors or ligands involved in chemotaxis-attenuated diet-induced insulin resistance [114,115,116], while over-expression of monocyte chemoattractant protein 1 (MCP1), a macrophage chemotactic protein that is also named C-C-Motif ligand 2 (CCL2), in adipose tissue increased the recruitment of macrophages and exacerbated obesity-induced insulin resistance in mice [117]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.