Conversely, a deficiency in macrophage migration inhibitory factor (MIF), a pro-inflammatory factor with chemokine-like properties, reduced high-fat diet-mediated M1 macrophage infiltration in white adipose tissue compared to wild-type mice and resulted in a partial protection from diet-induced insulin resistance by alleviating tissue inflammation in MIF-deficient mice compared to wildtype littermates [118]. This evidence concerns the gene MIF and Insulin resistance.