Three days after the treatment with clodronate liposomes, a significantly higher hepatic lipid accumulation, impaired hepatic insulin receptor signaling and a worsened homeostatic model assessment of insulin resistance (HOMA-IR) were observed that went along with an abrogation of diet-induced IL-10 production in these livers, indicating that Kupffer cells alternatively activated by the high-fat diet intervention might be the main source for this insulin-sensitizing cytokine [131]. This evidence concerns the gene INSR and Insulin resistance.