Salicylaldehyde was previously used as an inhibitor of the mRNA splicing of XBP1, a transcription factor, and H2O2-induced CXCL16 secretion was suppressed in salicylaldehyde-treated keratinocytes with a decrease in the production of the spliced XBP1 protein [18] and the XBP-1-dependent proliferation was also inhibited in salicylaldehyde-treated melanoma cells [19]. This evidence concerns the gene CXCL16 and melanoma.