In our previous study, stellettin B inhibited invasion and angiogenesis in glioblastoma [18]; in addition, we found that stellettin B at as low a concentration as 0.1 nM yields neuroprotection by regulating the nuclear factor erythroid 2-related factor 2/heme-oxygenase 1 (Nrf2/HO-1) pathway in vitro and in vivo [19]. This evidence concerns the gene HMOX1 and glioblastoma.