Remarkable coincidence of the effects of antidepressant treatment, 5-HT7 knockout and pharmacological blockade of 5-HT7 receptors indicates that 5-HT7 receptor facilitates the mechanisms provoking depression and suggest that 5-HT7 antagonists might have therapeutic value as novel antidepressant drugs [235,241,242]. The gene discussed is HTR7; the disease is major depressive disorder.