Svegliati-Baroni et al. [98] reported that the expression of the glucagon-like peptide-1 receptor (GLP-1r) is reduced in the hepatocytes of rats fed diet HF and patients with NASH, and that the activation of GLP-1r in the hepatocytes increased the oxidation of β-fatty acids and improved the insulin sensitivity. The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.