Sirtuins modulate the organismal lifespan by interacting with several lifespan regulating signaling pathways, including the insulin/IGF-1 signaling pathway, TOR, AMPK, FOXO, and the NAD+-dependent sirtuin deacetylases that are commonly dysregulated in aging and ARDs [90,93,94]. This evidence concerns the gene IGF1 and acute respiratory distress syndrome.