IL1A and psoriasis: Although the exact physiological concentrations of hBDs are not well known, the doses of hBD-2 have been estimated to be 3.5–16 μM (15–70 μg/mL) in IL-1α-stimulated epidermal cultures [36] and approximately 20 μM (87 μg/mL) in skin tissues from patients with psoriasis [37].