AQP1, a gene of Colton blood system, has prognostic significance in most cancer types, including the association of good outcomes in seven types of cancers, i.e., HNSC, SARC, LIHC, KIRP, KICH, MESO, KIRC and poor outcomes in three cancers (LUSC, LGG, UVM). This evidence concerns the gene AQP1 and cancer.