BSG and cancer: For example, BSG (CD147), an OK blood group antigen system gene, is described to be upregulated in several human cancers [9,10], including cervical squamous cell carcinoma [11], increased BSG expression is significantly associated with a higher pathologic stage, tumor size, invasion depth, lymphoid infiltration, and a number of other prognostic parameters in cervical squamous cell carcinoma and renal clear cell carcinoma [12,13,14].