MAPT and Alzheimer disease: Concerning the kinases, the mitogen-activated protein kinases (MAPKs) govern meaningful cellular programs and are crucial intermediate pathways in signaling, while microtubule affinity-regulating kinase 4 (MARK4) is a part of the kinases family recognized for actively phosphorylating neural microtubule-associated proteins (MAPs), i.e., MAP2, MAP4, and especially important for AD, tau protein.