STAT1 and cancer: Lamichhane et al. found that miR-452, a miRNA with differential expression patterns reported based on cancer type, directly targets IL20RA in CRC cell lines to decrease inflammatory protein regulators such as JAK1, STAT1, and STAT3, but interestingly, the inhibition of miR-452 did not rescue STAT1 levels, indicating that miR-452 does not directly modulate it [57].