Reduced ICD signal for JUP, Cx43, and SAP97; all were normalized by SB216763 (GSK3β inhibitor).SB216763 treatment increased Cx43 protein levels.Abnormal GSK3β localization, and SB216763 normalizes it. Dsg2mut/mut mice with constitutively active GSK3β demonstrated increased myocardial fibrosis and cardiac dysfunction. Here, GJA1 is linked to Myocardial fibrosis.