Regarding AD, in healthy specimens, 30%CR is enough to reduce the number and size of age-associated accumulation of amyloid plaques, astrocyte activation and Tau phosphorylation in multiple brain regions, including the hippocampus, cortex, neocortex, dentate gyrus, and entorhinal cortex [87,88,89,90]. This evidence concerns the gene MAPT and Alzheimer disease.