As such, LPS has been shown to induce 15d-PGJ2 in primary rat microglial cultures [79], and Huang et al. (2015) revealed inhibition of microglial activation by i.p. 15d-PGJ2 treatment in a model of brain ischemia [80], potentially via NFκB inhibition [81]. The gene discussed is NFKB1; the disease is brain ischemia.