Relevant genes which are affected in both human PWS patients, PWS-patient-induced pluripotent stem cell (iPSC) derived neurons and PWS mouse models include insulin-like growth factor-binding protein 7 (Igfbp7), proprotein convertase subtilisin/kexin type 1 (Pcsk1) and nascent helix-loop-helix 2 (Nhlh2) [11,12,13]. The gene discussed is NHLH2; the disease is Prader-Willi syndrome.