Since no such behavioral alterations have been reported for PWScrm+/p− or Snord116m+/p− knock-out mouse models, it cannot be excluded whether perturbations in neuronal activity induced via a Snord116-Nlgn3 interaction may contribute to the complex behavioral symptoms observed in PWS patients [5,6,59]. Here, SNORD116 is linked to Prader-Willi syndrome.