CDKL5 and craniodiaphyseal dysplasia: Here, using a chronic luteolin treatment, we provide the first evidence that, by recovering microglia overactivation, hippocampal neurogenesis, dendritic pathology, and behavioral abnormalities were improved in heterozygous female Cdkl5 +/− mice, suggesting that luteolin, a natural flavonoid with anti-oxidant and anti-inflammatory properties [49,50,61,62], might have a therapeutic value in CDD.