CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 gene [1,2], is characterized by a complex symptomatology, including early infantile onset refractory epilepsy, hypotonia, and severe cognitive, motor, visual, and sleep disturbances [3]. This evidence concerns the gene CDKL5 and neurodevelopmental disorder.