Furthermore, this is consistent with previous studies that found rhEPO/heterodimeric EPOR binding results in a region-, time-, and cell-type-specific regulation of VEGF and ANGPT-2 expression in HI brain injury in neonatal rodents [21], while the pro-angiogenic effects of ANGPT-2, such as enhanced capillary endothelial cell proliferation and stimulating endothelial cell sprouting and migration and microvessel density depends on the presence of VEGF and Tie-2 binding [43,57]. This evidence concerns the gene TEK and injury.