Nevertheless, we have shown that the anti-inflammatory properties of rhGH cause a significant decrease in IL-2 and increase in IL-10 levels, which together with the activation of ERK1/2 signaling, found to mediate its neuroprotective effects in an experimental rodent stroke model by suppressing oxidative stress and pro-apoptotic pathways [27,70], may contribute to protecting BBB integrity in response to rhGH treatment during early development. This evidence concerns the gene MAPK3 and stroke disorder.