In the current study, PAD6 positive staining was observed at varying levels in a number of the animal cancers, including in rabbit mammary adenocarcinoma, parrot lymphoma, mink nephroblastoma, feline pulmonary carcinoma, equine liver carcinoma, bovine neuroendocrine tumour, multicentric malignant tumour (mesothelioma) of deer, pig lymphoma, canine anaplastic carcinoma and mixed germ cell-sex cord stromal tumour. This evidence concerns the gene PADI6 and cancer.