NPC1 and Cognitive impairment: In particular, in the neurodegenerative NPC disease, in which there is an accumulation of cholesterol and glycolipids in the lysosomes of oligodendrocytes [142], in parallel with a large dysfunction of the operation of these cells, a reduced level of adenosine has been shown in the brain of NPC1-/- mice; this was an experimental model of the disease, which was in turn coupled to impaired synaptic plasticity and cognitive deficits of the same animals [143].