LEKTI can diminish the activities of epidermal serine proteases such as KLK5, KLK6, KLK7, KLK13, and KLK14 in skin [34], and a mutation in the SPINK5 gene is characteristic of Netherton syndrome, which presents with serious dehydration, itching, and chronic skin inflammation. Here, KLK5 is linked to Netherton syndrome.