IGHE and Alzheimer disease: People affected by Netherton syndrome exhibit a wide range of chronic and severe skin allergic inflammations, such as AD with elevated serum immunoglobulin E (IgE) levels [10,11], and causes dehydration, mucosal epithelial infections, hyperlipidemia, hypothermia, and dramatic weight loss, which often lead to postnatal death due to severe changes in skin barrier function [12].