NGF is upregulated following SCI [52,53,54] and, while in perilesional locations’ NGF increase could help to promote some regeneration and protection of surviving neuronal circuits [68,69,70], it has also been associated with severe SCI outcomes, such as autonomic dysreflexia, urinary dysfunction and pain [54,58,71,72,73], all of which have been linked to abnormal axonal sprouting [44,71]. Here, NGF is linked to autonomic dysreflexia.