IL6 and liver disorder: In general, IL-6 binds to the interleukin-6 receptor (IL-6R), and the IL-6/IL-6R complex initiates glycoprotein 130 (gp130) for the activation of JAK/STAT, MAPK and PI3K/AKT, which is essential for the early onset of liver disease and the progression and maintenance of the regenerative process [52,53].