Analysis of the co-expression of CD38 and HLA-DR activation molecules on T lymphocytes revealed a higher frequency of CD38+HLA-DR+ in CD4+, CD8+, and CD8+ Temra memory cells (memory T cells that re-express CD45RA) in SLE patients than in individuals without ARDs [34]. The gene discussed is CD4; the disease is systemic lupus erythematosus.