GH1 and pituitary gland adenoma: In a recent exosome miRNA sequencing, 169 differently expressed miRNAs were found when comparing six serum samples from patients with GH-secreting pituitary adenomas and six samples from healthy individuals; however, during the validation step, only miR-320a and miR-423-5p showed statistical significance, and the same tendency was shown in both exosome miRNA sequencing and qPCR [61].