TP53 and ovarian carcinoma: While the half-maximal inhibitory concentration (IC50) values for wild-type p53 ovarian cancer cell lines, TOV-21G and A2780, were 9.73 μM and 28.31 μM, respectively, these values were greatly elevated in mutant p53 ovarian cancer cell lines, COV318 and COV362, with IC50 values of 127.6 μM and 120.4 μM, respectively (Table 1).