ABCG2 and colorectal carcinoma: The observed downregulation of ABCG2 in the more mesenchymal A549CisR cell line may be difficult to explain, but our data correspond well with previous findings, indicating that the downregulation of ABCG2, at both the mRNA and protein level, reverses the correlation with mesenchymal markers and acquisition of advance EMT in CRC cells (in vivo and in vitro) [57].