Importantly, our derived A549CisR cell line, representing an EMT phenotype, demonstrated ABCC1 and ABCC4 upregulation and ABCG2 downregulation; this relationship was observed for GSE108214, while ABCG2 repression has also been noted in advanced colorectal cancer cells undergoing EMT and patient samples [57]. The gene discussed is ABCC4; the disease is colorectal cancer.