H2S donor, Na2S and NaHS, administration has been demonstrated to elevate local and systemic inflammation, whereas DL-propargylglycine (an inhibitor of cystathionine-γ-lyase H2S-synthesizing enzyme) and neurokinin-1 receptor (substance P receptor) antagonist treatment protected against the sepsis-induced systemic inflammatory response and multiple organ dysfunction in mice [11,12,24]. The gene discussed is TACR1; the disease is Sepsis.