IL-8 plays a critical role in (1) the recruitment and accumulation of TAMs and the other immunosuppressive cells, such as regulatory T (Treg) cells, into the TME [2,11] and (2) neovascularization/tumor angiogenesis, accelerating tumor proliferation and metastasis in the TME [12]. The gene discussed is CXCL8; the disease is neoplasm.