Most TAMs have M2-like characteristics in the TME (up to 50% of the tumor mass in solid tumors) and secrete pro-inflammatory and anti-inflammatory cytokines/chemokines (i.e., IL-8/CXCL8 and IL-10) and angiogenic growth factors (i.e., transforming growth factor (TGF)-β1 and vascular endothelial growth factor (VEGF)) during tumor progression [2]. This evidence concerns the gene VEGFA and neoplasm.