In their study, Wanjalla et al. combined both bulk and single-cell RNA sequencing to identify CD4+ T-cells clonality in AIDS patients’ adipose tissue with or without diabetes and an HIV-negative diabetics’ control group, hypothesizing a role of latent pro-viral and/or replicating HIV and other HIV-associated viruses, such as CMV, in the development of glucose intolerance [103]. The gene discussed is CD4; the disease is AIDS.