LEP and obesity due to melanocortin 4 receptor deficiency: Our findings suggest that LRG1 might be part of a common pathway involved in the development of obesity, possibly through P38/MAPK signaling pathway, as LRG1 has been shown to correlate positively with HsCRP, chemerin, leptin, IL6, and IL10 and that all of them have been implicated in regulating P38/MAPK signaling pathway.