Considering the relationship between GRB14 and COBLL1 mRNA expression in AT with obesity and diabetes-related parameters, as well as taking into account the above-mentioned SNP associations with metabolic traits, we conducted mediation analyses by statistically simulating the causal relationship between rs10195252 and GRB14 mRNA expression in vis AT and HbA1c. This evidence concerns the gene COBLL1 and obesity due to melanocortin 4 receptor deficiency.