GRB14 and obesity due to melanocortin 4 receptor deficiency: Considering the relationship between GRB14 and COBLL1 mRNA expression in AT with obesity and diabetes-related parameters, as well as taking into account the above-mentioned SNP associations with metabolic traits, we conducted mediation analyses by statistically simulating the causal relationship between rs10195252 and GRB14 mRNA expression in vis AT and HbA1c.