TNF and acute respiratory distress syndrome: The follow-up research on this topic used LPS-induced ALI, LPS-induced bone marrow-derived macrophage (BMDM) cells, and IL-10 knockout mice to test H-SN1’s anti-inflammatory activity; the results suggested that H-SN1 has significant anti-inflammatory effects, both in vitro and in vivo, demonstrating H-SN1 to be a suitable candidate for use in the treatment of TNF-α-associated inflammatory diseases such as inflammatory bowel diseases [24,75].