In human cell line models of septic AKI, HK-2 cells treated with LPS showed elevated cytoplasmic expression of circ-FANCA, circ-BNIP3L, hsa_circ_0114427, hsa_circ_0114428, circ-HIPK3, and circ-TLK1, whereas knockout of circ-FANCA, circ-BNIP3L, hsa_circ_0114427, hsa_circ_0114428, circ-HIPK3, and circ-TLK1, respectively, resulted in the attenuation of LPS-induced cell injury, implying a direct pathogenic role of these circRNAs [31,32,34,35,36,37]. This evidence concerns the gene TLK1 and acute kidney injury.