BDNF and Alzheimer disease: Moreover, KEGG analysis indicated that both upregulated and downregulated lncRNAs were involved in the glutamatergic synapse, cell senescence, and the neurotrophin signaling pathway and enriched in biological processes associated with the regulation of synapse structure or activity, cerebral cortex cell migration, and cerebral cortex development, revealing potential mechanisms for the roles of these novel lncRNAs in AD.