When studying the effect of mouse embryonic stem cell transplantation on the severity of colitis and immune imbalance in pyrrolidone induced colitis in IL-10−/− KO mice, Srivastava et al. proved that induced pre-differentiated ESCs were able to colonize the small intestine, colon, and liver, as well as alleviate inflammation through mechanisms such as repairing damaged epithelium and reconstituting the immune system [155]. Here, IL10 is linked to colitis.