CHD5 and central nervous system cancer: We observed significant down regulation of CHD5 in 25 tumor types, including GBM, Glioma, LGG, UCEC, BRCA, CESC, LUAD, ESCA, STES, KIRP, KIPAN, COAD, COADREAD, PRAD, STAD, KIRC, LUSC, WT, SKCM, BLCA, THCA, OV, TGCT, UCS, and ACC, while there was a significant upregulation in 5 tumor types including HNSC, ALL, LAML, PCPG, and CHOL (p < 0.05) (Figure 1A).