Vinpocetin (39), a small chemical derived from the leaves of Phyllostachys pubescens, attenuates DEX-induced rat osteoblast apoptosis by 60% and 65% at 5 and 10 μM than that caused by DEX and inhibits the progression of osteonecrosis of the femoral head (ONFH) by lowering DEX-induced elevated levels of ROS by over 90% at 10 μM and activating the Akt pathway via Akt phosphorylation by over 2-fold at 10 μM. Here, AKT1 is linked to osteonecrosis.