In order to determine the still-not-understood role of α(1,6)FT during carcinogenesis and dissemination of CRC, the expression of the enzyme was reduced, in the present study, by knockdown of the FUT8 gene in a model of malignancy formed by the syngeneic SW480 (premetastatic) and SW620 (metastatic) tumor lines [17]. The gene discussed is FUT8; the disease is neoplasm.