VDR and liver disorder: In this review, we focus on the complex interaction between immune and liver cells in the maintenance of liver homeostasis and the development of liver injury, discuss advances in the molecular mechanisms of vitamin D–VDR signaling in the context of liver disease development and progression, present the recent findings on the role of vitamin D and VDR-associated genetic variants in regulating the occurrence and severity of liver disease, and finally summarize the therapeutic value of vitamin D supplementation.