Also, trial cooperation between the Ca2+ channel Orai1, SPCA2 protein, and Kv10.1 has been recognized with strong participation in intracellular Ca2+ entry but also plays a significant role in collagen-1-induced breast cancer cell survival via DDR (Discoidin-Domain Receptors), a specific collagen 1 receptor, that seems to be tightly involved in ERK1/2 phosphorylation [104]. This evidence concerns the gene KCNG3 and breast carcinoma.