Some hypotheses concluded that cell migration led by Kv10.1 channel could mainly trigger changes in microtubule dynamics as a result of hyperpolarization of action potential, which have been proved to induce calcium entry through ORAI1, and their association with secretory pathway Ca2+ ATPase (SPCA2) seems to be also implicated in proliferation and survival in cancer cells [99]. Here, KCNH1 is linked to cancer.