Today, it is known that renal tubular cells are able to produce interleukin 1β (IL-1β), interleukin 18 (IL-18) and tumor necrosis factor-alpha (TNF-α) [5,6,7] which, with diverse actions, are potentially involved in the development and complications of DN [8,9,10,11,12]. Here, IL18 is linked to liver dysplastic nodule.