MAPK7 and nonpapillary renal cell carcinoma: In the present study, we demonstrated that (1) ccRCC patients with strong ERK5 expression in their surgical specimens had poor survival; (2) the specimens with decreased miR-143 had higher rates of strong ERK5 expression; (3) ERK5 inhibition suppresses ccRCC-cell and endothelial-cell proliferation and survival in vitro and in vivo.