Investigating the IC50 of XMD8-92 in A498 (VHL mutant, low miR-143 expression, and strong ERK5 expression human ccRCC cells, Figure 3H), Caki1 (VHL wild type, low miR-143 expression, and weak ERK5 expression human RCC cells, Figure 3I), 769P (VHL mutant, high miR-143 expression, and weak ERK5 expression human ccRCC cells, Figure 3J), HUVEC (human endothelial cells, Figure 3K), and HRCEpC (normal urothelial cells, Figure 3L), the values were 9.6 μM, 26.5 μM, 28.6 μM, 7.4 μM, and 45.1 μM, respectively. Here, VHL is linked to nonpapillary renal cell carcinoma.