It was previously reported that oral SFN intake increases the mRNA and protein levels of Pgc1α, Nrf1, and Tfam in the liver of high-fat induced non-alcoholic fatty liver disease (NAFLD) model rats and in a free fatty acid-stimulated human hepatocyte (HHL-5) cell line [28]. This evidence concerns the gene NRF1 and metabolic dysfunction-associated steatotic liver disease.