Furthermore, IL-17 and IL-22 levels were much less induced by PAO1 in RAG and RAG γc KO mice (IL-22 was indeed indetectable in RAG γc KO mice (Figure 3C3,C4), strengthening the notion that the latter two cytokines are mainly produced by lymphocytes during the infection, and at least in part (for IL-17) explaining the neutrophil influx at that time point (16 h). The gene discussed is SMOX; the disease is infection.