ACTA1 and Hernia: On the other hand, according to Rosch and colleagues’ study, which was conducted in hernia patients, significant increase in c-myc expression correlated to the decreased collagen I/III ratios [86] and, in the recent study of Shen et al., demonstrated that c-Myc siRNA inhibited the Ang II–induced accumulation of ECM renal proteins, including fibronectin, collagen I, and α-SMA [85].