As human HCC cells are extremely heterogeneous, the correlation of TLR4 with inflammatory cytokines was investigated; we confirmed that the expression of TLR4 is positively correlated with inflammatory cytokines such as IL6 and C-C motif chemokine ligand 2 (CCL2), and that TLR4 activation promotes HCC. This evidence concerns the gene CCL2 and hepatocellular carcinoma.