Using glioma cells, TrkB-T1 activation is found to dissociate the Rho guanine nucleotide dissociation inhibitor (Rho GDI1), thereby reducing the activity of RhoA, Rho-associated kinase (ROCK), p21-activated kinase (PAK), and extracellular-signal regulated kinase-1/2 (ERK1/2) [50]. The gene discussed is MAPK3; the disease is central nervous system cancer.