Its upregulation, and subsequent BDNF-dependent activation, in neurons is supported to underlie the attenuation of ischemia-induced apoptosis by quercetin [61] and hippocampal neuronal injury in stroke via heme oxygenase 1 [62] as well as the cognitive enhancing action of L-3-n-butylphthalide in Alzheimer’s mice [63], anti-parkinsonian neuroprotection of curcumin [64], improved recovery from traumatic brain injury (TBI) by simvastatin [65], alleviation of oxidative glutamate toxicity by huperzine A [66], and the antidepressant action of liquiritigenin [67]. This evidence concerns the gene BDNF and stroke disorder.