On the other hand, augmenting BDNF transmission rescues plasticity impairments in certain brain regions in murine models of Alzheimer’s disease [176], Huntington’s disease [177], fragile X syndrome [178], chronic intermittent hypoxia [179], schizophrenia [180], and aging [181]. The gene discussed is BDNF; the disease is early-onset autosomal dominant Alzheimer disease.