[10.1016/j.nbd.2004.01.015] (accessed on 26 July 2022) Amyloid beta (Aβ), known to cause Alzheimer’s disease, is hypothesized to accumulate in the brain as plaques and is regulated by receptors for ApoE [150,151,152]. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.