Indeed, other molecules, such as fibroblast growth factor 21 (FGF-21) and cytokeratin 18 (CK-18), have been suggested as biomarkers for NAFLD [89], although a link between TM4SF5 and CK-18 has not been explored [89,90]. This evidence concerns the gene TM4SF5 and metabolic dysfunction-associated steatotic liver disease.