SIRT1 and metabolic dysfunction-associated steatohepatitis: Meanwhile, TM4SF5-positive NASH patients also show obvious increases in TM4SF5-related molecules, such as SIRT1, CCL2, CCL5, and laminin γ2 [36], and TM4SF5-dependent CXCL10 and CCL20 are involved in macrophage activation and repolarization [9].