TSPAN5 and hepatocellular carcinoma: Certain tetraspanins known as HCC risk factors have been shown to play roles in HCC growth, survival, neoangiogenesis, invasiveness, and migration [65]; they include CD151, TSPAN5, CD9, CD82, CD63, etc. In terms of HCC, abnormal metabolic pathways and activties can be involved in the development of liver maligancies.