Evaluating pre and post values, Hesperidin was able to reduce the serum levels of glucose (p < 0.001), insulin (p < 0.001), the homeostasis model assessment of insulin resistance (HOMA-IR) (−0.70, p < 0.001) TG (p = 0.002), TC (p < 0.001), LDL-c (p = 0.010), TNF-α (p < 0.001) and hs-CRP (p = 0.008). The gene discussed is INS; the disease is Insulin resistance.