SOD2 and type 2 diabetes nephropathy: The observation of increased peroxynitrite generation in the glomeruli of these mice is in line with our previous report on experimental type 2 diabetic nephropathies, where reduced renal Sirt3 expression was associated with the hyperacetylation of the antioxidant enzyme superoxide dismutase 2 and a concomitant increase in glomerular oxidative stress and mitochondrial abnormalities mainly found in podocytes [20].